HYBRIDIZATION APPROACH TO IDENTIFY SALICYLANILIDES AS INHIBITORS OF TUBULIN POLYMERIZATION AND SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3 (STAT3)

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, Ex Boyfriend Jean and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands.This structural information led us to propose hybrids of TUB015 and nocodazole using a salicylanilide core

A vehicle accident report system was designed to detect accidents accurately and send message to related person.However, after accident, some components or modules can be damaged and it may cause failure of Rocks accident detection.Therefore, Triple Modular Redundancy (TMR) method was implemented in the system to mask faults within the modules and

Paul Saenger Division of Pediatric Endocrinology, Department of Pediatrics, Winthrop University Hospital, Mineola, NY, USA Abstract: Recombinant human growth hormone (rhGH) has been in clinical use for more than 30 years.With the expiration of patent exclusivity for the first wave of rhGH products and other biopharmaceuticals, the opportunity emerg

Introduction: Integrated care has been posited as an important strategy for overcoming service fragmentation problems and achieving the Quadruple Aim of health care.This paper describes the Central Coast Integrative Care Program Knife Sharpeners (CCICP) a complex, multi-component intervention addressing 3 target populations and more than 40 sub-pro